Atrial Fibrillation and Endothelial Dysfunction

نویسندگان

چکیده

Atrial fibrillation (AF) is the most common cardiac arrhythmia, and coronary atherosclerosis leading cause of death in United States worldwide. Endothelial dysfunction earliest clinically detectable form atherosclerosis. Control shared AF risk factors improves both AF-free survival vascular endothelial function. Decades research have yielded fundamental insight into pathophysiology, but current pharmacological catheter-based invasive therapies limited long-term efficacy substantial side effects, possibly because incomplete understanding underlying complex pathophysiology. We hereby discuss potential mechanistic links between (risk-factor–associated systemic inflammation oxidative stress, myocardial ischemia, gene variants, shear fibroblast growth factor-23), explore a new dimension to highlight growing body evidence supporting an association dysfunction, AF, stroke, effective therapies.

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ژورنال

عنوان ژورنال: Mayo Clinic Proceedings

سال: 2021

ISSN: ['1942-5546', '0025-6196']

DOI: https://doi.org/10.1016/j.mayocp.2020.11.005